Structure of PDB 5cg9 Chain A Binding Site BS04

Receptor Information
>5cg9 Chain A (length=267) Species: 5762 (Naegleria gruberi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMINKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHD
GSVELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYV
TADLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALN
NCLYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLE
LTDKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKP
YYEDTQKNSLKIHKETK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain5cg9 Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5cg9 Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.
Resolution2.693 Å
Binding residue
(original residue number in PDB)		H229 D231 H279
Binding residue
(residue number reindexed from 1)		H175 D177 H225
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
External links
PDB RCSB:5cg9, PDBe:5cg9, PDBj:5cg9
PDBsum5cg9
PubMed26323320
UniProtD2W6T1|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

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