Structure of PDB 4w8y Chain A Binding Site BS04

Receptor Information
>4w8y Chain A (length=835) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVNIKEKLFVYLHDPPDKALKIENHEERSKKILSSGNIQDKVKQADALSS
KTQRFIIREPVIDFLGRFHVGYPVFIHPISTEIKRYETLEKYIDLGRSNR
GERFVNEFLERVSKLEGDVLKEVFEDASNKFKGEESKQWAYIWQFYPVKL
KEGVKEFAKSELKLKEEEAEKFAEEFVNLPADTRFPDHAIWTHLDLTSAL
SVKDPTLLRIKIVPVQPFIANSRKQLDLWASSHLLSMLMYKALEVIVDKF
GPEHVIYPSLRDQPFFLKFYLGENIGDEILVANLPNKALAIVSGKEAEKI
EEEIKKRIRDFLLQLYREAVDWAVENGVVKVDRSEKDSMLKEAYLKIVRE
YFTVSITWVSLSEKEDIYQVTENAGLSDEDVKKWLKFAEKKENSRVLERI
AIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYDH
DNLKSLWLDEEPLCPMCLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNW
RKIFDEKYGKDLVSKAREVSEDFVKDNMLVDSDLYYSSTWESGLSIDEEK
VKEVVDFLNAAYKEIGNPPKYYAILVMDGDDMGKVISGEVLGEISTRIHP
NIRDYVEIPEAKYYSTPQVHVAISQALANFSIREVRSVVKDEGLLIYAGG
DDVLAILPVDKALEVAYKIRKEFGKSFENGSLLPGWKLSAGILIVHYKHP
LYDALEKARDLLNNKAKNVPGKDTLAIGLLKRSGSYYISLVGWELIRVFY
NSELRKKLLERFIYHVLREVDTWPIDEMLKFEVIRHIKEETKELREKIYG
EIKDLLEHVRGNNEVEKVRGLFTFLKIITDAEVFP
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4w8y Chain A Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4w8y Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D600 D673 D674
Binding residue
(residue number reindexed from 1)		D578 D651 D652
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4w8y, PDBe:4w8y, PDBj:4w8y
PDBsum4w8y
PubMed25280103
UniProtQ8U1S6|CMR2_PYRFU CRISPR system Cmr subunit Cmr2 (Gene Name=cmr2)

[Back to BioLiP]