Structure of PDB 4o6a Chain A Binding Site BS04
Receptor Information
>4o6a Chain A (length=361) Species:
10090
(Mus musculus) [
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MPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL
NTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRG
NPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVT
LLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPF
YLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRK
ECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNL
SSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEY
ERNNGFPIFDK
Ligand information
>4o6a Chain F (length=17) [
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tttcgtcttcggcaatt
Receptor-Ligand Complex Structure
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PDB
4o6a
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Resolution
1.859 Å
Binding residue
(original residue number in PDB)
K315 R342
Binding residue
(residue number reindexed from 1)
K170 R197
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4o6a
,
PDBe:4o6a
,
PDBj:4o6a
PDBsum
4o6a
PubMed
24462292
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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