Structure of PDB 4lpj Chain A Binding Site BS04

Receptor Information

>4lpj Chain A (length=174) Species: 8400 (Aquarana catesbeiana)

VSQVRQNYHSDCEAAVNRMLNLELYASYTYSSMYAFFDRDDVALHNVAEF
FKEHSHEEREHAEKFMKYQNKRGGRVVLQDIKKPERDEWGNTLEAMQAAL
QLEKTVNQALLDLHKLATDKVDPHLCDFLESEYLEEQVKDIKRIGDFITN
LKRLGLPENGMGEYLFDKHSVKES

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4lpj Chain A Residue 212

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4lpj Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
• Resolution: 1.27 Å
• Binding residue (original residue number in PDB): E103 Q137 D140
• Binding residue (residue number reindexed from 1): E103 Q137 D140
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.16.3.1: ferroxidase.

Gene Ontology

Molecular Function

• GO:0004322 ferroxidase activity
• GO:0008198 ferrous iron binding
• GO:0008199 ferric iron binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006826 iron ion transport
• GO:0006879 intracellular iron ion homeostasis
• GO:0006880 intracellular sequestering of iron ion

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4lpj, PDBe:4lpj, PDBj:4lpj
• PDBsum: 4lpj
• PubMed: 25849404
• UniProt: P07798|FRI2_AQUCT Ferritin, middle subunit