Structure of PDB 4j2x Chain A Binding Site BS04

Receptor Information

>4j2x Chain A (length=420) Species: 10090 (Mus musculus)

PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLM
GSGWKKKKEQMETDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAK
TLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKN
ADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLD
DDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDA
DDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGA
SWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQ
NFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPV
TLVRNDGVIYSTSLTFTYTP

Ligand information

>4j2x Chain H (length=15)

ttactgtgggaaaga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4j2x Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling.
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): K90 R91 F92 K192 R218 S221 T223 K295 K311
• Binding residue (residue number reindexed from 1): K38 R39 F40 K140 R166 S169 T171 K243 K259
• Binding affinity: PDBbind-CN: Kd=0.011uM

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4j2x, PDBe:4j2x, PDBj:4j2x
• PDBsum: 4j2x
• PubMed: 24290140
• UniProt: P31266|SUH_MOUSE Recombining binding protein suppressor of hairless (Gene Name=Rbpj)