Structure of PDB 4it0 Chain A Binding Site BS04

Receptor Information

>4it0 Chain A (length=480) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VVPLKRIDKIRWEIPKFDKRMRVPGRVYADEVLLEKMKNDRTLEQATNVA
MLPGIYKYSIVMPDGHQGYGFPIGGVAAFDVKEGVISPGGIGYDINCGVR
LIRTNLTEKEVRPRIKQLVDTLFKNVPSGVGSQGRIKLHWTQIDDVLVDG
AKWAVDNGYGWERDLERLEEGGRMEGADPEAVSQRAKQRGAPQLGSLGSG
NHFLEVQVVDKIFDPEVAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRI
MERAIRKYRIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITH
WVRESFQEVFKQDPEGDLGMDIVYDVAHNIGKVEEHEVDGKRVKVIVHRK
GATRAFPPGHEAVPRLYRDVGQPVLIPGSMGTASYILAGTEGAMKETFGS
TCHGAGRVLSRKAATRQYRGDRIRQELLNRGIYVRAASMRVVAEEAPGAY
KNVDNVVKVVSEAGIAKLVARMRPIGVAKG

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

4it0 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4it0 Structures of the Noncanonical RNA Ligase RtcB Reveal the Mechanism of Histidine Guanylylation.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	D95 C98 H203
Binding residue (residue number reindexed from 1)	D94 C97 H202
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.-.-
6.5.1.8: 3'-phosphate/5'-hydroxy nucleic acid ligase.

Gene Ontology

	Molecular Function
GO:0008452	RNA ligase activity

	Biological Process
GO:0006396	RNA processing

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Molecular Function

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Biological Process

External links

PDB	RCSB:4it0, PDBe:4it0, PDBj:4it0
PDBsum	4it0
PubMed	23560983
UniProt	O59245\|RTCB_PYRHO tRNA-splicing ligase RtcB (Gene Name=rtcB)

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