Structure of PDB 4gyf Chain A Binding Site BS04

Receptor Information

>4gyf Chain A (length=263) Species: 272623 (Lactococcus lactis subsp. lactis Il1403) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SLKKLDYHFHSHFSADSEELPRKHVTEAIAHGLEEICFTEHRDFYFPGMD
FSLNLPEYFQEINQLQAEFKDKIKIKIGLEMGIDLRFKSEINQFIDSAPF
DFVIASVHEIGDIEVYDGTEFYLQKTKEEAQREYLLACLDVVQNFENYNS
FGHLDYVARYGPYTDKSIKFAENREILFEILRALASKEKALEINTRLFDD
PKTEQFYSDLLINFKRLGGKFITLGTDSHIAKRDWLSIHKARTLIKKAGF
HELATFSGMKIDK

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4gyf Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4gyf Crystal structure of histidinol phosphate phosphatase (HISK) from Lactococcus lactis subsp. lactis Il1403 complexed with ZN, L-histidinol and phosphate
Resolution	1.647 Å
Binding residue (original residue number in PDB)	H32 H240
Binding residue (residue number reindexed from 1)	H31 H239
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.15: histidinol-phosphatase.

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004401	histidinol-phosphatase activity
GO:0016787	hydrolase activity

	Biological Process
GO:0000105	L-histidine biosynthetic process

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:4gyf, PDBe:4gyf, PDBj:4gyf
PDBsum	4gyf
PubMed
UniProt	Q02150\|HIS9_LACLA Histidinol-phosphatase (Gene Name=hisK)

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