Structure of PDB 4ene Chain A Binding Site BS04

Receptor Information
>4ene Chain A (length=444) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMG
ALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGAL
EDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIF
RLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIK
AVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFG
PIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGG
FNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTV
LGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMT
DNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain4ene Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4ene Intracellular proton access in a cl(-)/h(+) antiporter.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R205 Y210
Binding residue
(residue number reindexed from 1)		R189 Y194
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0015297 antiporter activity
GO:0042802 identical protein binding
GO:0062158 chloride:proton antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990451 cellular stress response to acidic pH
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ene, PDBe:4ene, PDBj:4ene
PDBsum4ene
PubMed23239938
UniProtP37019|CLCA_ECOLI H(+)/Cl(-) exchange transporter ClcA (Gene Name=clcA)

[Back to BioLiP]