Structure of PDB 4dd7 Chain A Binding Site BS04

Receptor Information
>4dd7 Chain A (length=129) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL
Ligand information
Ligand IDDMS
InChIInChI=1S/C2H6OS/c1-4(2)3/h1-2H3
InChIKeyIAZDPXIOMUYVGZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[S](C)=O
ACDLabs 10.04sulfinyldimethane
OpenEye OEToolkits 1.5.0CS(=O)C
FormulaC2 H6 O S
NameDIMETHYL SULFOXIDE
ChEMBLCHEMBL504
DrugBankDB01093
ZINCZINC000005224188
PDB chain4dd7 Chain A Residue 205 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4dd7 Structural studies of the effect that dimethyl sulfoxide (DMSO) has on cisplatin and carboplatin binding to histidine in a protein.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		R5 A122 W123
Binding residue
(residue number reindexed from 1)		R5 A122 W123
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E35 N46 D48 S50 D52 N59
Catalytic site (residue number reindexed from 1) E35 N46 D48 S50 D52 N59
Enzyme Commision number 3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0005515 protein binding
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
Biological Process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dd7, PDBe:4dd7, PDBj:4dd7
PDBsum4dd7
PubMed22525758
UniProtP00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)

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