Structure of PDB 4c4n Chain A Binding Site BS04

Receptor Information
>4c4n Chain A (length=151) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKD
EENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEES
LHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAE
N
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4c4n Chain A Residue 1192 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4c4n Structural Insights Into Proteoglycan-Shaped Hedgehog Signaling.
Resolution2.36 Å
Binding residue
(original residue number in PDB)		E91 E127 D130 D132 H134
Binding residue
(residue number reindexed from 1)		E52 E88 D91 D93 H95
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:4c4n, PDBe:4c4n, PDBj:4c4n
PDBsum4c4n
PubMed24062467
UniProtQ62226|SHH_MOUSE Sonic hedgehog protein (Gene Name=Shh)

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