Structure of PDB 4au7 Chain A Binding Site BS04

Receptor Information
>4au7 Chain A (length=243) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPTLRRQHHLRSALE
AFLRQRDLEAAFRALTLGGWMAHYFQSRAPRQEAALKTHIFCYLRAFLPE
SGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREEDEDLL
RAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPSDGNTACVKV
LRDIEPGDEVTCFYGEGFFGEKNEHCECYTCERKGEGAFRLQP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4au7 Chain A Residue 1249 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4au7 A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		H92 C95 C141
Binding residue
(residue number reindexed from 1)		H89 C92 C138
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4au7, PDBe:4au7, PDBj:4au7
PDBsum4au7
PubMed24049080
UniProtQ6Q783|KMT5C_MOUSE Histone-lysine N-methyltransferase KMT5C (Gene Name=Kmt5c)

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