Structure of PDB 4a36 Chain A Binding Site BS04

Receptor Information

>4a36 Chain A (length=523) Species: 8839 (Anas platyrhynchos)

KKARSYQIELAQPAINGKNALICAPTGSGKTFVSILICEHHFQNMPAGRK
AKVVFLATKVPVYEQQKNVFKHHFERQGYSVQGISGENFSNVSVEKVIED
SDIIVVTPQILVNSFEDGTLTSLSIFTLMIFDECHNTTGNHPYNVLMTRY
LEQKFNSASQLPQILGLTASVGVGNAKNIEETIEHICSLCSYLDIQAIST
VRENIQELQRFMNKPEIDVRLVKRRIHNPFAAIISNLMSETEALMRTIFG
TQNYEHWIVVTQRKCREEESRICRALFICTEHLRKYNDALIISEDARIID
ALSYLTEFFTNVKNGPYTELEQHLTAKFQEKEPELIALSKDETNENPKLE
ELVCILDDAYRYNPQTRTLLFAKTRALVSALKKCMEENPILNYIKPGVLM
GRGMTLPSQKGVLDAFKTSKDNRLLIATSVADEGIDIVQCNLVVLYEYSG
NVTKMIQVRGRGRAAGSKCILVTSKTEVVENEKCNRYKEEMMNKAVEKIQ
KWDEETFAKKIHNLQMKERVLRD

Ligand information

• Ligand ID: AF3
• InChI: InChI=1S/Al.3FH/h;3*1H/q+3;;;/p-3
• InChIKey: KLZUFWVZNOTSEM-UHFFFAOYSA-K
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: F[Al](F)F
• Formula: Al F3
• Name: ALUMINUM FLUORIDE
• PDB chain: 4a36 Chain A Residue 1796

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4a36 Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): K273 E376 G704 R731 R733
• Binding residue (residue number reindexed from 1): K30 E133 G434 R461 R463
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:4a36, PDBe:4a36, PDBj:4a36
• PDBsum: 4a36
• PubMed: 22000019
• UniProt: D3TI84