Structure of PDB 3w5n Chain A Binding Site BS04

Receptor Information
>3w5n Chain A (length=1029) Species: 227882 (Streptomyces avermitilis MA-4680 = NBRC 14893) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALRVTSPSVEYVQRPLGLDAAHPRLSWPMASAAPGRRQSAYQVRVASSAA
GLSHPDVWDSGKVVSDDSVLVPYAGPPLKPRTRYFWSVRVWDADGGASEW
SAPSWWETGLMGASQWSAKWISAPAPLTEAPSLEGSSWIWFPEGEPANSA
PAATRWFRRTVDLPDDITGATLAISADNVYAVSVDGAEVARTDLEADNEG
WRRPAVIDVLDHVHSGNNTLAVSASNASVGPAGWICVLVLTTASGEKKIF
SDASWKSTDHEPADGWREPDFDDSGWPAAKVAAAWGAGPWGRVAPVASAA
NQLRHEFRLPHKKVSRARLYATALGLYEAHLNGRRVGRDQLAPGWTDYRK
RVQYQTYDVTSSVRPGANALAAYVAPGWYAGNVGMFGPHQYGERPALLAQ
LEVEYADGTSERITSGPDWRAASGPIVSADLLSGETYDARKETAGWTSPG
FDDRAWLAVRGADNDVPEQIVAQVDGPVRIAKELPARKVTEPKPGVFVLD
LGQNMVGSVRLRVSGDAGTTVRLRHAEVLNPDGTIYTANLRSAAATDTYT
LKGQGEETYEPRFTFHGFRYVEVTGFPGKPSTTSVTGRVMHTSAPFTFEF
ETNVPMLNKLHSNITWGQRGNFLSVPTDTPARDERLGWTGDINVFAPTAA
YTMESARFLTKWLVDLRDAQTSDGAFTDVAPAVGNLGNGVAGWGDAGVTV
PWALYQAYGDRQVLADALPSVHAWLRYLEKHSDGLLRPADGYGDWLNVSD
ETPKDVIATAYFAHSADLAARMATELGKDAAPYTDLFTRIRKAFQTAYVA
SDGKVKGDTQSAYVLTLSMNLVPDALRKAAADRLVALIEAKDWHLSTGFL
GTPRLLPVLTDTGHTDVAYRLLHQRTFPSWGYPIDKGSTTMWERWDSIQP
DGGFQTPEMNSFNHYAYGSVGEWMYANIAGIAPGRAGYRQVVIRPRPGGE
VTSARATFASLHGPVSTRWQQRSGGFVLTCSVPPNTTAEVWIPADHPDRV
QHTHGTFVRAEDGCAVFEVGSGSHRFTVK
Ligand information
Ligand IDRAM
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3-,4+,5+,6+/m0/s1
InChIKeySHZGCJCMOBCMKK-HGVZOGFYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H](O)[C@H](O)[C@H](O)[C@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O)O)O)O
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namealpha-L-rhamnopyranose;
alpha-L-rhamnose;
6-deoxy-alpha-L-mannopyranose;
L-rhamnose;
rhamnose
ChEMBL
DrugBank
ZINCZINC000003861280
PDB chain3w5n Chain A Residue 1204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3w5n The structure of a Streptomyces avermitilis alpha-L-rhamnosidase reveals a novel carbohydrate-binding module CBM67 within the six-domain arrangement.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		K484 F598 R621
Binding residue
(residue number reindexed from 1)		K482 F596 R619
Annotation score5
Enzymatic activity
Enzyme Commision number 3.2.1.40: alpha-L-rhamnosidase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0030596 alpha-L-rhamnosidase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3w5n, PDBe:3w5n, PDBj:3w5n
PDBsum3w5n
PubMed23486481
UniProtQ82PP4|RHA78_STRAW Alpha-L-rhamnosidase (Gene Name=SAVERM_828)

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