Structure of PDB 3mfi Chain A Binding Site BS04

Receptor Information
>3mfi Chain A (length=511) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPHMSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSK
EDPVVCVQWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKK
GEDFWQYHDGCGSWVQDPAKQISVEDHKVSLEPYRRESRKALAIFKWACD
LVERASIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGG
NYDINSHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILALGSQVCKG
IRDSIKDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDC
GKFEITSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLD
AKVKQSDYDSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSNKN
LRGKSCNSIVDCISWLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLKTK
SYEVYRKSGPVAYKGINFQSHELLKVGIKFVTDLDIKGKNKSYYPLTKLS
MTITNFDIIDL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3mfi Chain A Residue 515 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3mfi Structural basis for the suppression of skin cancers by DNA polymerase eta.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		D30 M31 D155
Binding residue
(residue number reindexed from 1)		D33 M34 D158
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mfi, PDBe:3mfi, PDBj:3mfi
PDBsum3mfi
PubMed20577207
UniProtQ04049|POLH_YEAST DNA polymerase eta (Gene Name=RAD30)

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