Structure of PDB 3maq Chain A Binding Site BS04

Receptor Information
>3maq Chain A (length=776) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHMAQAGFILTRHWRDTPQGTEVSFWLATDNGPLQVTLAPQESVAFIPAD
QVPRAQHILQGEQGFRLTPLALKDFHRQPVYGLYCRAHRQLMNYEKRLRE
GGVTVYEADVRPPERYLMERFITSPVWVEGDMHNGTIVNARLKPHPDYRP
PLKWVSIDIETTRHGELYCIGLEGCGQRIVYMLGPENGDASSLDFELEYV
ASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRLPLRLGR
DNSELEWREHGFKNGVFFAQAKGRLIIDGIEALKSAFWNFSSFSLETVAQ
ELLGEGDRMDEIDRRFAEDKPALATYNLKNCELVTQIFHKTEIMPFLLER
ATVNGLPVDRHGGSVAAFGHLYFPRMHRAGYVAPNLGEVPPHASPGGYVM
DSRPGLYDSVLVLDYKSLYPSIIRTFLIDPVGLVEGMAQPDPEHSTEGFL
DAWFSREKHCLPEIVTNIWHGRDEAKRQGNKPLSQALKIIMNAFYGVLGT
TACRFFDPRLASSITMRGHQIMRQTKALIEAQGYDVIYGDTDSTFVWLKG
AHSEEEAAKIGRALVQHVNAWWAETLQKQRLTSALELEYETHFCRFLMPT
IRGADTGSKKRYAGLIQEGDKQRMVFKGLETVRTDWTPLAQQFQQELYLR
IFRNEPYQEYVRETIDKLMAGELDARLVYRKRLRRPLSEYQRNVPPHVRA
ARLADEENQKRGRPLQYQNRGTIKYVWTTNGPEPLDYQRSPLDYEHYLTR
QLQPVAEGILPFIEDNFATLMTGQLF
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3maq Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3maq Structural insight into translesion synthesis by DNA Pol II
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D419 Y420 D547
Binding residue
(residue number reindexed from 1)		D414 Y415 D542
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008296 3'-5'-DNA exonuclease activity
Biological Process
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0009432 SOS response
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3maq, PDBe:3maq, PDBj:3maq
PDBsum3maq
PubMed20064374
UniProtP21189|DPO2_ECOLI DNA polymerase II (Gene Name=polB)

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