Structure of PDB 3m6z Chain A Binding Site BS04

Receptor Information

>3m6z Chain A (length=372) Species: 190192 (Methanopyrus kandleri AV19) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VYDAEFVGSEREFEEERETFLKGVKAYDGVLATRYLMERSSSAKNDEELL
ELHQNFILLTGSYACSIDPTEDRYQNVIVRGVNFDERVQRLSTGGSPARY
AIVYRRGWRAIAKALDIDEEDVPAIEVRAVKRNPLQPALYRILVRYGRVD
LMPVTVDEVPPEMAGEFERLIERYDVPIDEKEERILEILRENPWTPHDEI
ARRLGLSVSEVEGEKDPESSGIYSLWSRVVVNIEYDERTAKRHVKRRDRL
LEELYEHLEELSERYLRHPLTRRWIVEHKRDIMRRYLEQRIVECALKLQD
RYGIREDVALCLARAFDGSISMIATTPYRTLKDVCPDLTLEEAKSVNRTL
ATLIDEHGLSPDAADELIEHFE

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

3m6z Chain A Residue 384 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3m6z Structures of minimal catalytic fragments of topoisomerase v reveals conformational changes relevant for DNA binding.
Resolution	1.4 Å
Binding residue (original residue number in PDB)	S210 V211 A327 V349 N350 R351
Binding residue (residue number reindexed from 1)	S207 V208 A324 V346 N347 R348
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:3m6z, PDBe:3m6z, PDBj:3m6z
PDBsum	3m6z
PubMed	20637419
UniProt	Q977W1

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