Structure of PDB 3ffk Chain A Binding Site BS04

Receptor Information
>3ffk Chain A (length=347) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLR
NGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFES
ATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVP
VSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSG
RARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKVS
NGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEE
RKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3ffk Chain A Residue 759 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ffk Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E302 D303 E327
Binding residue
(residue number reindexed from 1)		E275 D276 E300
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:3ffk, PDBe:3ffk, PDBj:3ffk
PDBsum3ffk
PubMed19666512
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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