Structure of PDB 3f66 Chain A Binding Site BS04

Receptor Information
>3f66 Chain A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLKIH
CAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVV
LPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLA
ARNCMLDEKFTVKVADFGLARDMYDKEYYSVAKLPVKWMALESLQTQKFT
TKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDP
LYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHY
Ligand information
Ligand IDGBL
InChIInChI=1S/C4H6O2/c5-4-2-1-3-6-4/h1-3H2
InChIKeyYEJRWHAVMIAJKC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1CC(=O)OC1
ACDLabs 10.04O=C1OCCC1
CACTVS 3.341O=C1CCCO1
FormulaC4 H6 O2
NameGAMMA-BUTYROLACTONE;
DIHYDROFURAN-2(3H)-ONE
ChEMBLCHEMBL95681
DrugBankDB04699
ZINCZINC000004658567
PDB chain3f66 Chain A Residue 5 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3f66 Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		P1176 D1180 F1216
Binding residue
(residue number reindexed from 1)		P120 D124 F160
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222 A1243
Catalytic site (residue number reindexed from 1) D148 A150 R152 N153 D166 A182
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3f66, PDBe:3f66, PDBj:3f66
PDBsum3f66
PubMed19059779
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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