Structure of PDB 3dsl Chain A Binding Site BS04

Receptor Information
>3dsl Chain A (length=416) Species: 8724 (Bothrops jararaca) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKYNPFRYVELFIVVDQGMVTKNNGDLDKIKARMYELANIVNEILRYLYM
HAALVGLEIWSNGDKITVKPDVDYTLNSFAEWRKTDLLTRKKHDNAQLLT
AIDFNGPTIGYAYIGSMCHPKRSVAIVEDYSPINLVVAVIMAHEMGHNLG
IHHDTDFCSCGDYPCIMGPTISNEPSKFFSNCSYIQCWDFIMKENPQCIL
NEPLGTDIVSPPVCGNELLEVGEECDCGTPENCQNECCDAATCKLKSGSQ
CGHGDCCEQCKFSKSGTECRASMSECDPAEHCTGQSSECPADVFHKNGQP
CLDNYGYCYNGNCPIMYHQCYALFGADVYEAEDSCFKDNQKGNYYGYCRK
ENGKKIPCAPEDVKCGRLYCKDNSPGQNNPCKMFYSNDDEHKGMVLPGTK
CADGKVCSNGHCVDVA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3dsl Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3dsl The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: Insights for a new classification of snake venom metalloprotease subgroups.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		H145 H149 H155
Binding residue
(residue number reindexed from 1)		H143 H147 H153
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.49: bothropasin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3dsl, PDBe:3dsl, PDBj:3dsl
PDBsum3dsl
PubMed18831982
UniProtO93523|VM3BP_BOTJA Zinc metalloproteinase-disintegrin-like bothropasin

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