Structure of PDB 2xyb Chain A Binding Site BS04

Receptor Information

>2xyb Chain A (length=497) Species: 5643 (Trametes cinnabarina)

AIGPVADLTLTNAQVSPDGFAREAVVVNGITPAPLITGNKGDRFQLNVID
QLTNHTMLKTSSIHWHGFFQQGTNWADGPAFVNQCPIASGHSFLYDFQVP
DQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPHASLYDIDNDDTVITLAD
WYHVAAKLGPRFPFGSDSTLINGLGRTTGIAPSDLAVIKVTQGKRYRFRL
VSLSCDPNHTFSIDNHTMTIIEADSINTQPLEVDSIQIFAAQRYSFVLDA
SQPVDNYWIRANPAFGNTGFAGGINSAILRYDGAPEIEPTSVQTTPTKPL
NEVDLHPLSPMPVPGSPEPGGVDKPLNLVFNFNGTNFFINDHTFVPPSVP
VLLQILSGAQAAQDLVPEGSVFVLPSNSSIEISFPATANAPGFPHPFHLH
GHAFAVVRSAGSSVYNYDNPIFRDVVSTGQPGDNVTIRFETNNPGPWFLH
CHIDFHLDAGFAVVMAEDTPDTKAANPVPQAWSDLCPIYDALDPSDL

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 2xyb Chain A Residue 504

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2xyb Purification, Crystallisation and X-Ray Diffraction Study of Fully Functional Laccases from Two Ligninolytic Fungi.
• Resolution: 1.75 Å
• Binding residue (original residue number in PDB): H64 H398 H400
• Binding residue (residue number reindexed from 1): H64 H398 H400
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H64 H66 H109 H111 H395 H398 H400 H450 C451 H452 I453 H456 F461
• Catalytic site (residue number reindexed from 1): H64 H66 H109 H111 H395 H398 H400 H450 C451 H452 I453 H456 F461
• Enzyme Commision number: 1.10.3.2: laccase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:2xyb, PDBe:2xyb, PDBj:2xyb
• PDBsum: 2xyb
• UniProt: Q9UVQ2