Structure of PDB 2x2f Chain A Binding Site BS04

Receptor Information
>2x2f Chain A (length=336) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFSMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFV
GRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIE
AETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDI
EFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIG
VITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAAL
AAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQS
QLLSIEKEVEEYSRVDEMLRMYHALKEALSIIGNIN
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain2x2f Chain A Residue 1750 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2x2f G Domain Dimerization Controls Dynamin'S Assembly-Stimulated Gtpase Activity.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S41 G60 S61 G62 V64
Binding residue
(residue number reindexed from 1)		S39 G58 S59 G60 V62
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2x2f, PDBe:2x2f, PDBj:2x2f
PDBsum2x2f
PubMed20428113
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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