Structure of PDB 2wsd Chain A Binding Site BS04

Receptor Information

>2wsd Chain A (length=505) Species: 1423 (Bacillus subtilis)

TLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLPPTRLWGY
NGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHEEPEVKTVVHL
HGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHA
MALTRLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSL
FYPSAPENPSPSLPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVIN
ASNTRTYNLSLDNGGDFIQIGSDGGLLPRSVKLNSFSLAPAERYDIIIDF
TAYEGESIILANSAGCGGDVNPETDANIMQFRVTKPLAQKDESRKPKYLA
SYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKRWHDPVTETPKVGTT
EIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYTGPAVPP
PPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHALEHEDYDMMRPM
DITDP

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 2wsd Chain A Residue 604

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wsd Proximal Mutations at the Type 1 Copper Site of Cota Laccase: Spectroscopic, Redox, Kinetic and Structural Characterization of I494A and L386A Mutants.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): H105 H422 H424
• Binding residue (residue number reindexed from 1): H99 H416 H418
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.10.3.2: laccase.
  1.3.3.5: bilirubin oxidase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0030435 sporulation resulting in formation of a cellular spore

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space

External links

• PDB: RCSB:2wsd, PDBe:2wsd, PDBj:2wsd
• PDBsum: 2wsd
• PubMed: 18307408
• UniProt: P07788|COTA_BACSU Laccase (Gene Name=cotA)