Structure of PDB 2w7p Chain A Binding Site BS04

Receptor Information

>2w7p Chain A (length=431) Species: 9606 (Homo sapiens)

KEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKA
QLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGS
MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK
EILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKNSVVFGTS
AQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNR
QAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSE
TSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELC
SELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAK
ELLKTEIDADFPHPLRLRLMGVRISSFPNEE

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2w7p Chain A Residue 1522

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2w7p Structural and Functional Elucidation of the Mechanism Promoting Error-Prone Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-Oxo-2'-Deoxyguanosine Adduct.
• Resolution: 3.71 Å
• Binding residue (original residue number in PDB): D107 D325
• Binding residue (residue number reindexed from 1): D75 D236
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:2w7p, PDBe:2w7p, PDBj:2w7p
• PDBsum: 2w7p
• PubMed: 19542228
• UniProt: Q9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)