Structure of PDB 2oo4 Chain A Binding Site BS04

Receptor Information
>2oo4 Chain A (length=226) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWD
YINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCNQGCNS
EECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLH
TNLRIKRDSQGELMVYPYYGEVAGSKVFLEIDNRQCVQDSDHCFKNTDAA
AALLASHAIQGTLSYPLVSVVSESLT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2oo4 Chain A Residue 6001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2oo4 Structural basis for autoinhibition of Notch
Resolution2.003 Å
Binding residue
(original residue number in PDB)		E1525 H1574 H1638
Binding residue
(residue number reindexed from 1)		E101 H150 H192
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:2oo4, PDBe:2oo4, PDBj:2oo4
PDBsum2oo4
PubMed17401372
UniProtQ04721|NOTC2_HUMAN Neurogenic locus notch homolog protein 2 (Gene Name=NOTCH2)

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