Structure of PDB 2mzh Chain A Binding Site BS04

Receptor Information
>2mzh Chain A (length=248) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLP
ITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRD
LPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPF
DGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHALGHS
LGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2mzh Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2mzh Charge-Triggered Membrane Insertion of Matrix Metalloproteinase-7, Supporter of Innate Immunity and Tumors.
ResolutionN/A
Binding residue
(original residue number in PDB)		D71 H194 H198 H204
Binding residue
(residue number reindexed from 1)		D72 H195 H199 H205
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H194 A195 H198 H204
Catalytic site (residue number reindexed from 1) H195 A196 H199 H205
Enzyme Commision number 3.4.24.23: matrilysin.
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0002779 antibacterial peptide secretion
GO:0002780 antibacterial peptide biosynthetic process
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0009410 response to xenobiotic stimulus
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0031293 membrane protein intracellular domain proteolysis
GO:0042127 regulation of cell population proliferation
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2mzh, PDBe:2mzh, PDBj:2mzh
PDBsum2mzh
PubMed26439767
UniProtP09237|MMP7_HUMAN Matrilysin (Gene Name=MMP7)

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