Structure of PDB 2m48 Chain A Binding Site BS04

Receptor Information
>2m48 Chain A (length=141) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEYVLQAGGVLCPQPGCGMGLLVEPDCRKVTCQNGCGYVFCRNCLQGYHI
GECLPEGTGASATNSCEYTVDPNRAAEARWDEASNVTIKVSTKPCPKCRT
PTERDGGCMHMVCTRAGCGFEWCWVCQTEWTRDCMGAHWFG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2m48 Chain A Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2m48 A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.
ResolutionN/A
Binding residue
(original residue number in PDB)		C464 H479
Binding residue
(residue number reindexed from 1)		C123 H138
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2m48, PDBe:2m48, PDBj:2m48
PDBsum2m48
PubMed23770917
UniProtQ7KTX7|PRKN_DROME E3 ubiquitin-protein ligase parkin (Gene Name=park)

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