Structure of PDB 2ju4 Chain A Binding Site BS04

Receptor Information
>2ju4 Chain A (length=87) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEPPKAECRSATRVMGGPCTPRKGPPKCKQRQTRQCKSKPPKKGVQGC
GDDIPGMEGCGTDITVICPWEACNHCELHELAQYGIC
Ligand information
Ligand IDRCY
InChIInChI=1S/C12H20N2O3/c1-11(2)7-8(12(3,4)14(11)17)13-9(15)5-6-10(13)16/h8,17H,5-7H2,1-4H3/t8-/m1/s1
InChIKeyBGLGHMPQDJUKJG-MRVPVSSYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6CC1(CC(C(N1[O])(C)C)N2C(=O)CCC2=O)C
CACTVS 3.370CC1(C)C[C@@H](N2C(=O)CCC2=O)C(C)(C)N1[O]
ACDLabs 12.01ON2C(CC(N1C(=O)CCC1=O)C2(C)C)(C)C
CACTVS 3.370CC1(C)C[CH](N2C(=O)CCC2=O)C(C)(C)N1[O]
OpenEye OEToolkits 1.7.6CC1(C[C@H](C(N1[O])(C)C)N2C(=O)CCC2=O)C
FormulaC12 H19 N2 O3
Name(3'R)-1'-oxyl-2',2',5',5'-tetramethyl-1,3'-bipyrrolidine-2,5-dione;
3-Maleimido-PROXYL (bound form)
ChEMBL
DrugBank
ZINC
PDB chain2ju4 Chain A Residue 138 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ju4 Intrinsically disordered gamma-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure.
ResolutionN/A
Binding residue
(original residue number in PDB)		R33 C38 C50 G51 D52 P55
Binding residue
(residue number reindexed from 1)		R33 C38 C50 G51 D52 P55
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0030553 cGMP binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0060090 molecular adaptor activity
Biological Process
GO:0007601 visual perception
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
Cellular Component
GO:0042622 photoreceptor outer segment membrane
GO:0097381 photoreceptor disc membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ju4, PDBe:2ju4, PDBj:2ju4
PDBsum2ju4
PubMed18230733
UniProtP04972|CNRG_BOVIN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (Gene Name=PDE6G)

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