Structure of PDB 2iie Chain A Binding Site BS04

Receptor Information
>2iie Chain A (length=204) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGGSGGLTKA
EMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRD
KNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENAGGGERIEIRGFG
SFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYGGSGHH
HHHH
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2iie Chain A Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2iie A Divalent Metal-mediated Switch Controlling Protein-induced DNA Bending
Resolution2.41 Å
Binding residue
(original residue number in PDB)		E54 D58
Binding residue
(residue number reindexed from 1)		E54 D58
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001216 DNA-binding transcription activator activity
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006310 DNA recombination
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0006417 regulation of translation
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009295 nucleoid
GO:0032993 protein-DNA complex
GO:1990177 IHF-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2iie, PDBe:2iie, PDBj:2iie
PDBsum2iie
PubMed17276457
UniProtP0A6X7|IHFA_ECOLI Integration host factor subunit alpha (Gene Name=ihfA);
P0A6Y1|IHFB_ECOLI Integration host factor subunit beta (Gene Name=ihfB)

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