Structure of PDB 1yvp Chain A Binding Site BS04

Receptor Information
>1yvp Chain A (length=529) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDQTQPLNEKQVPNSEGCYVWQVSDMNRLRRFLCFGSEGGTYYIEEKKLG
QENAEALLRLIEDGKGCEVVQEIKTFSQEGRAAKQEPTLFALAVCSQCSD
IKTKQAAFRAVPEVCRIPTHLFTFIQFKKDLKEGMKCGMWGRALRKAVSD
WYNTKDALNLAMAVTKYKQRNGWSHKDLLRLSHIKPANEGLTMVAKYVSK
GWKEVQEAYKEKELSPETEKVLKYLEATERVKRTKDELEIIHLIDEYRLV
REHLLTIHLKSKEIWKSLLQDMPLTALLRNLGKMTADSVLAPASSEVSSV
CERLTNEKLLKKARIHPFHILVALETYKKGHGLRWIPDTSIVEALDNAFY
KSFKLVEPTGKRFLLAIDVSASMNQRVLGSILNASVVAAAMCMLVARTEK
DSHMVAFSDEMLPCPITVNMLLHEVVEKMSDITMGSTDCALPMLWAQKTN
TAADIFIVFTDCETNVEDVHPATALKQYREKMGIPAKLIVCAMTSNGFSI
ADPDDRGMLDICGFDSGALDVIRNFTLDL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1yvp Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1yvp Structural Insights into RNA Quality Control: The Ro Autoantigen Binds Misfolded RNAs via Its Central Cavity
Resolution2.2 Å
Binding residue
(original residue number in PDB)		S378 S380 T445
Binding residue
(residue number reindexed from 1)		S370 S372 T437
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0034336 misfolded RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0030030 cell projection organization
Cellular Component
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1yvp, PDBe:1yvp, PDBj:1yvp
PDBsum1yvp
PubMed15907467
UniProtP42700|RO60_XENLA RNA-binding protein RO60 (Gene Name=ro60)

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