Structure of PDB 1y63 Chain A Binding Site BS04

Receptor Information

>1y63 Chain A (length=168) Species: 347515 (Leishmania major strain Friedlin)

EQPKGINILITGTPGTGKTSMAEMIAAELDGFQHLEVGKLVKENHFYTET
HIIEEKDEDRLLDFMEPIMVSRGNHVVDYHSSELFPERWFHMVVVLHTST
EVLFERLTKRQYSEAKRAENMEAEIQCICEEEARDAYEDDIVLVRENDTL
EQMAATVEEIRERVEVLK

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 1y63 Chain A Residue 355

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1y63 Crystal structural analysis of a probable kinase from Leishmania major Friedlin
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): Y123 N131
• Binding residue (residue number reindexed from 1): Y112 N120
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.4.3: adenylate kinase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004017 adenylate kinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0016887 ATP hydrolysis activity
• GO:0042134 rRNA primary transcript binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0006979 response to oxidative stress
• GO:0009267 cellular response to starvation
• GO:0016310 phosphorylation
• GO:0030490 maturation of SSU-rRNA
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis
• GO:0046940 nucleoside monophosphate phosphorylation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005929 cilium
• GO:0010494 cytoplasmic stress granule
• GO:0031981 nuclear lumen

External links

• PDB: RCSB:1y63, PDBe:1y63, PDBj:1y63
• PDBsum: 1y63
• UniProt: Q4Q7A6