Structure of PDB 1xhv Chain A Binding Site BS04

Receptor Information
>1xhv Chain A (length=254) Species: 727 (Haemophilus influenzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFIKPIYQDINSILIGQKVKRPTLSGHAAGEPFEKLVYKFLKENLSDLTF
KQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENL
FEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAK
MIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAA
AMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFK
KYIL
Ligand information
Receptor-Ligand Complex Structure
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PDB1xhv Mechanistic Insights from the Structures of HincII Bound to Cognate DNA Cleaved from Addition of Mg(2+) and Mn(2+)
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E38 D114 T130 N132 S136 A137 Q138 P140 N141
Binding residue
(residue number reindexed from 1)		E34 D110 T126 N128 S132 A133 Q134 P136 N137
Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
Biological Process
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:1xhv, PDBe:1xhv, PDBj:1xhv
PDBsum1xhv
PubMed15476804
UniProtP17743|T2C2_HAEIF Type II restriction enzyme HincII (Gene Name=hincIIR)

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