Structure of PDB 1tkj Chain A Binding Site BS04

Receptor Information
>1tkj Chain A (length=277) Species: 1911 (Streptomyces griseus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APDIPLANVKAHLTQLSTIAANNGGNRAHGRPGYKASVDYVKAKLDAAGY
TTTLQQFTSGGATGYNLIANWPGGDPNKVLMAGAHLDSVSSGAGINDNGS
GSAAVLETALAVSRAGYQPDKHLRFAWWGAEELGLIGSKFYVNNLPSADR
SKLAGYLNFDMIGSPNPGYFVYDDDPVIEKTFKNYFAGLNVPTEIETEGD
GRSDHAPFKNVGVPVGGLFTGAGYTKSAAQAQKWGGTAGQAFDRCYHSSC
DSLSNINDTALDRNSDAAAHAIWTLSS
Ligand information
Ligand IDMED
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1
InChIKeyFFEARJCKVFRZRR-SCSAIBSYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
CACTVS 3.341CSCC[C@@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@H](C(=O)O)N
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameD-METHIONINE
ChEMBLCHEMBL1234268
DrugBankDB02893
ZINCZINC000001532766
PDB chain1tkj Chain A Residue 913 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1tkj Interactions of D Amino Acids with Streptomyces griseus Aminopeptidase
Resolution1.15 Å
Binding residue
(original residue number in PDB)		H85 D97 E131 E132 D160 M161 R202 F219 Y246 H247
Binding residue
(residue number reindexed from 1)		H85 D97 E131 E132 D160 M161 R202 F219 Y246 H247
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N77 D97 E131 E132 D160
Catalytic site (residue number reindexed from 1) N77 D97 E131 E132 D160
Enzyme Commision number 3.4.11.24: aminopeptidase S.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1tkj, PDBe:1tkj, PDBj:1tkj
PDBsum1tkj
PubMed
UniProtP80561|APX_STRGG Aminopeptidase S (Gene Name=SGR_5809)

[Back to BioLiP]