Structure of PDB 1oe6 Chain A Binding Site BS04
Receptor Information
>1oe6 Chain A (length=244) Species:
8355
(Xenopus laevis) [
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SPADSFLKVELELNLKLSNLVFQDPVQYVYNPLVYAWAPHENYVQTYCKS
KKEVLFLGMNPGPFGMAQTGVPFGEVNHVRDWLQIEGPVSKPEVEHPKRR
IRGFECPQSEVSGARFWSLFKSLCGQPETFFKHCFVHNHCPLIFMNHSGK
NLTPTDLPKAQRDTLLEICDEALCQAVRVLGVKLVIGVGRFSEQRARKAL
MAEGIDVTVKGIMHPSPRNPQANKGWEGIVRGQLLELGVLSLLT
Ligand information
Ligand ID
HMU
InChI
InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)
InChIKey
JDBGXEHEIRGOBU-UHFFFAOYSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
C1=C(C(=O)NC(=O)N1)CO
ACDLabs 10.04
O=C1C(=CNC(=O)N1)CO
CACTVS 3.341
OCC1=CNC(=O)NC1=O
Formula
C5 H6 N2 O3
Name
5-HYDROXYMETHYL URACIL;
5-(HYDROXYMETHYL)PYRIMIDINE-2,4(1H,3H)-DIONE
ChEMBL
CHEMBL1233360
DrugBank
ZINC
ZINC000000114121
PDB chain
1oe6 Chain A Residue 1283 [
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Receptor-Ligand Complex Structure
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PDB
1oe6
Structure and Specificity of the Vertebrate Anti-Mutator Uracil-DNA Glycosylase Smug1
Resolution
2.65 Å
Binding residue
(original residue number in PDB)
E146 V147
Binding residue
(residue number reindexed from 1)
E110 V111
Annotation score
1
Enzymatic activity
Enzyme Commision number
3.2.2.-
Gene Ontology
Molecular Function
GO:0017065
single-strand selective uracil DNA N-glycosylase activity
Biological Process
GO:0006284
base-excision repair
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Molecular Function
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Biological Process
External links
PDB
RCSB:1oe6
,
PDBe:1oe6
,
PDBj:1oe6
PDBsum
1oe6
PubMed
12820976
UniProt
Q9YGN6
|SMUG1_XENLA Single-strand selective monofunctional uracil DNA glycosylase (Gene Name=smug1)
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