Structure of PDB 1n7d Chain A Binding Site BS04

Receptor Information
>1n7d Chain A (length=639) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVTCKSGDFSCGGNRCIPQFWRCDGQVDCNGSDEQGCPPKTCSQDEFRCH
DGRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDP
DCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPD
CKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCV
NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDN
NGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL
EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHERKMTLDRSEYTSL
IPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGSSYDTVISRDI
PDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFREQGSKPRAIVVD
PVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL
YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIIN
EAIFSANRLTGSDVNLLAENLLSPEDMVLFHQLTQPRGVNWCERTTLSNG
GCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1n7d Chain A Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1n7d Structure of the LDL receptor extracellular domain at endosomal pH
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R232 Q233 E237 D239 D245 E246
Binding residue
(residue number reindexed from 1)		R182 Q183 E187 D189 D195 E196
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:1n7d, PDBe:1n7d, PDBj:1n7d
PDBsum1n7d
PubMed12459547
UniProtP01130|LDLR_HUMAN Low-density lipoprotein receptor (Gene Name=LDLR)

[Back to BioLiP]