Structure of PDB 1lok Chain A Binding Site BS04

Receptor Information

>1lok Chain A (length=291) Species: 671 (Vibrio proteolyticus)

MPPITQQATVTAWLPQVDASQITGTISSLESFTNRFYTTTSGAQASDWIA
SEWQALSASLPNASVKQVSHSGYNQKSVVMTITGSEAPDEWIVIGGHLDS
TIGSHTNEQSVAPGADDDASGIAAVTEVIRVLSENNFQPKRSIAFMAYAA
EEVGLRGSQDLANQYKSEGKNVVSALQLDMTNYKGSAQDVVFITDYTDSN
FTQYLTQLMDEYLPSLTYGFDTCGYACSDHASWHNAGYPAAMPFESKFND
YNPRIHTTQDTLANSDPTGSHAKKFTQLGLAYAIEMGSATG

Ligand information

• Ligand ID: SCN
• InChI: InChI=1S/CHNS/c2-1-3/h3H/p-1
• InChIKey: ZMZDMBWJUHKJPS-UHFFFAOYSA-M
• SMILES:
  OpenEye OEToolkits 1.5.0: C(#N)[S-]
  ACDLabs 10.04
  CACTVS 3.341: [S-]C#N
• Formula: C N S
• Name: THIOCYANATE ION
• PDB chain: 1lok Chain A Residue 1973

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1lok The 1.20 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica Complexed with Tris A tale of Buffer Inhibition
• Resolution: 1.2 Å
• Binding residue (original residue number in PDB): N171 V172 Y238
• Binding residue (residue number reindexed from 1): N171 V172 Y238
• Annotation score: 3

Enzymatic activity

• Catalytic site (original residue number in PDB): H97 D117 E151 E152 D179 H256
• Catalytic site (residue number reindexed from 1): H97 D117 E151 E152 D179 H256
• Enzyme Commision number: 3.4.11.10: bacterial leucyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0008235 metalloexopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1lok, PDBe:1lok, PDBj:1lok
• PDBsum: 1lok
• PubMed: 12176384
• UniProt: Q01693|AMPX_VIBPR Bacterial leucyl aminopeptidase