Structure of PDB 1g5n Chain A Binding Site BS04

Receptor Information
>1g5n Chain A (length=318) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALRGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARSNAQRQQI
AEEFKTLFGRDLVNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGA
GTDEKVLTEIIASRTPEELRAIKQAYEEEYGSNLEDDVVGDTSGYYQRML
VVLLQANRDPDTAIDDAQVELDAQALFQAGELKWGTDEEKFITILGTRSV
SHLRRVFDKYMTISGFQIEETIDRETSGNLENLLLAVVKSIRSIPAYLAE
TLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSLYSMIKGD
TSGDYKKALLLLCGGEDD
Ligand information
Ligand IDIDS
InChIInChI=1S/C6H10O10S/c7-1-2(8)4(16-17(12,13)14)6(11)15-3(1)5(9)10/h1-4,6-8,11H,(H,9,10)(H,12,13,14)/t1-,2-,3+,4+,6+/m0/s1
InChIKeyCOJBCAMFZDFGFK-VCSGLWQLSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1(C(C(OC(C1OS(=O)(=O)O)O)C(=O)O)O)O
OpenEye OEToolkits 1.5.0[C@@H]1([C@@H]([C@@H](O[C@H]([C@@H]1OS(=O)(=O)O)O)C(=O)O)O)O
CACTVS 3.341O[CH]1O[CH]([CH](O)[CH](O)[CH]1O[S](O)(=O)=O)C(O)=O
CACTVS 3.341O[C@@H]1O[C@H]([C@@H](O)[C@H](O)[C@H]1O[S](O)(=O)=O)C(O)=O
ACDLabs 10.04O=S(=O)(OC1C(O)C(O)C(OC1O)C(=O)O)O
FormulaC6 H10 O10 S
Name2-O-sulfo-alpha-L-idopyranuronic acid;
O2-SULFO-GLUCURONIC ACID;
2-O-sulfo-alpha-L-iduronic acid;
2-O-sulfo-L-iduronic acid;
2-O-sulfo-iduronic acid
ChEMBL
DrugBankDB02264
ZINCZINC000004096028
PDB chain1g5n Chain C Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1g5n Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		S202 R205 R206
Binding residue
(residue number reindexed from 1)		S201 R204 R205
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
GO:0017046 peptide hormone binding
GO:0030971 receptor tyrosine kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0007596 blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0043065 positive regulation of apoptotic process
GO:0050819 negative regulation of coagulation
GO:0051592 response to calcium ion
GO:0070588 calcium ion transmembrane transport
GO:0071284 cellular response to lead ion
GO:0097066 response to thyroid hormone
GO:0097211 cellular response to gonadotropin-releasing hormone
GO:1901317 regulation of flagellated sperm motility
GO:1902721 negative regulation of prolactin secretion
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0009897 external side of plasma membrane
GO:0012506 vesicle membrane
GO:0014704 intercalated disc
GO:0030018 Z disc
GO:0030425 dendrite
GO:0030672 synaptic vesicle membrane
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0072563 endothelial microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1g5n, PDBe:1g5n, PDBj:1g5n
PDBsum1g5n
PubMed11342135
UniProtP14668|ANXA5_RAT Annexin A5 (Gene Name=Anxa5)

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