Structure of PDB 1f5a Chain A Binding Site BS04

Receptor Information
>1f5a Chain A (length=463) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YGITSPISLAAPKETDCLLTQKLVETLKPFGVFEEEEELQRRILILGKLN
NLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCV
APRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDIL
FARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDN
FRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLV
HKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPA
YPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQ
KYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQ
SFPAKEEFRTMWVIGLVFKDLTYDIQSFTDTVYRQAINSKMFEVDMKIAA
MHVKRKQLHQLLP
Ligand information
Ligand ID3PO
InChIInChI=1S/H5O10P3/c1-11(2,3)9-13(7,8)10-12(4,5)6/h(H,7,8)(H2,1,2,3)(H2,4,5,6)
InChIKeyUNXRWKVEANCORM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O
OpenEye OEToolkits 1.5.0OP(=O)(O)OP(=O)(O)OP(=O)(O)O
ACDLabs 10.04O=P(OP(=O)(O)OP(=O)(O)O)(O)O
FormulaH5 O10 P3
NameTRIPHOSPHATE
ChEMBLCHEMBL1230191
DrugBankDB03896
ZINCZINC000006827739
PDB chain1f5a Chain A Residue 4000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1f5a Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		A112 D113
Binding residue
(residue number reindexed from 1)		A93 D94
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) S102 D113 D115 D167 K228 Y237
Catalytic site (residue number reindexed from 1) S83 D94 D96 D148 K209 Y218
Enzyme Commision number 2.7.7.19: polynucleotide adenylyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016779 nucleotidyltransferase activity
GO:1990817 poly(A) RNA polymerase activity
Biological Process
GO:0031123 RNA 3'-end processing
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1f5a, PDBe:1f5a, PDBj:1f5a
PDBsum1f5a
PubMed10944102
UniProtP25500|PAPOA_BOVIN Poly(A) polymerase alpha (Gene Name=PAPOLA)

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