Structure of PDB 1cw0 Chain A Binding Site BS04

Receptor Information

>1cw0 Chain A (length=155) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ADVHDKATRSKNMRAIATRDTAIEKRLASLLTGQGLAFRVQDASLPGRPD
FVVDEYRCVIFTHGCFWHHHHCYLFKVPATRTEFWLEKIGKNVERDRRDI
SRLQELGWRVLIVWECALRGREKLTDEALTERLEEWICGEGASAQIDTQG
IHLLA

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1cw0 Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1cw0 Recognition of a TG mismatch: the crystal structure of very short patch repair endonuclease in complex with a DNA duplex.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	C66 H71 C73 C117
Binding residue (residue number reindexed from 1)	C65 H70 C72 C116
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	D51 T63 H69 D97
Catalytic site (residue number reindexed from 1)	D50 T62 H68 D96
Enzyme Commision number	3.1.-.-

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0043765	T/G mismatch-specific endonuclease activity
GO:0046872	metal ion binding

	Biological Process
GO:0006281	DNA repair
GO:0006298	mismatch repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:1cw0, PDBe:1cw0, PDBj:1cw0
PDBsum	1cw0
PubMed	10612397
UniProt	P09184\|VSR_ECOLI DNA mismatch endonuclease Vsr (Gene Name=vsr)

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