Structure of PDB 1blf Chain A Binding Site BS04

Receptor Information
>1blf Chain A (length=685) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVRWCTISQPEWFKCRRWQWRMKKLGAPSITCVRRAFALECIRAIAEKKA
DAVTLDGGMVFEAGRDPYKLRPVAAEIYGTKESPQTHYYAVAVVKKGSNF
QLDQLQGRKSCHTGLGRSAGWIIPMGILRPYLSWTESLEPLQGAVAKFFS
ASCVPCIDRQAYPNLCQLCKGEGENQCACSSREPYFGYSGAFKCLQDGAG
DVAFVKETTVFENLPEKADRDQYELLCLNNSRAPVDAFKECHLAQVPSHA
VVARSVDGKEDLIWKLLSKAQEKFGKNKSRSFQLFGSPPGQRDLLFKDSA
LGFLRIPSKVDSALYLGSRYLTTLKNLRETAEEVKARYTRVVWCAVGPEE
QKKCQQWSQQSGQNVTCATASTTDDCIVLVLKGEADALNLDGGYIYTAGK
CGLVPVLAENRKSSKHSSLDCVLRPTEGYLAVAVVKKANEGLTWNSLKDK
KSCHTAVDRTAGWNIPMGLIVNQTGSCAFDEFFSQSCAPGADPKSRLCAL
CAGDDQGLDKCVPNSKEKYYGYTGAFRCLAEDVGDVAFVKNDTVWENTNG
ESTADWAKNLNREDFRLLCLDGTRKPVTEAQSCHLAVAPNHAVVSRSDRA
AHVKQVLLHQQALFGKNGKNCPDKFCLFKSETKNLLFNDNTECLAKLGGR
PTYEEYLGTEYVTAIANLKKCSTSPLLEACAFLTR
Ligand information
Ligand IDCO3
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)([O-])[O-]
ACDLabs 10.04
CACTVS 3.341		[O-]C([O-])=O
FormulaC O3
NameCARBONATE ION
ChEMBL
DrugBankDB14531
ZINC
PDB chain1blf Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1blf Three-dimensional structure of diferric bovine lactoferrin at 2.8 A resolution.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D60 Y92 R121 S122 A123 Y192
Binding residue
(residue number reindexed from 1)		D56 Y88 R117 S118 A119 Y188
Annotation score3
Enzymatic activity
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0001503 ossification
GO:0001817 regulation of cytokine production
GO:0002227 innate immune response in mucosa
GO:0002376 immune system process
GO:0006508 proteolysis
GO:0006826 iron ion transport
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032680 regulation of tumor necrosis factor production
GO:0033690 positive regulation of osteoblast proliferation
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0045669 positive regulation of osteoblast differentiation
GO:0060349 bone morphogenesis
GO:1900159 positive regulation of bone mineralization involved in bone maturation
GO:1900229 negative regulation of single-species biofilm formation in or on host organism
GO:1902732 positive regulation of chondrocyte proliferation
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000308 negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2001205 negative regulation of osteoclast development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0042581 specific granule
GO:0055037 recycling endosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1blf, PDBe:1blf, PDBj:1blf
PDBsum1blf
PubMed9398529
UniProtP24627|TRFL_BOVIN Lactotransferrin (Gene Name=LTF)

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