Structure of PDB 1axn Chain A Binding Site BS04

Receptor Information
>1axn Chain A (length=323) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSN
AQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLK
KSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSG
DFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEI
LCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNT
PAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLY
SAIKSDTSGDYEITLLKICGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1axn Chain A Residue 354 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1axn The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.
Resolution1.78 Å
Binding residue
(original residue number in PDB)		K230 L233 E238
Binding residue
(residue number reindexed from 1)		K229 L232 E237
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006909 phagocytosis
GO:0010595 positive regulation of endothelial cell migration
GO:0021766 hippocampus development
GO:0031100 animal organ regeneration
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0045766 positive regulation of angiogenesis
GO:0051054 positive regulation of DNA metabolic process
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0070848 response to growth factor
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030670 phagocytic vesicle membrane
GO:0042581 specific granule
GO:0043025 neuronal cell body
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1axn, PDBe:1axn, PDBj:1axn
PDBsum1axn
PubMed8639653
UniProtP12429|ANXA3_HUMAN Annexin A3 (Gene Name=ANXA3)

[Back to BioLiP]