Structure of PDB 1avc Chain A Binding Site BS04

Receptor Information
>1avc Chain A (length=642) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YRGSIRDFPDFNPSQDAETLYNAMKGFGSDKEAIINLITSRSNKQRQEIC
QNYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYADAKEIKDAISGIG
TDEKCLIEILASRTNEQIHQLVAAYKDAYERDLEADITGDTSGHFRKMLV
VLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQ
HLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTAEYFAER
LFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDT
SGEYKKTLLKLCGGQFFPEAAQVAYQMWELSAVARVELKGTVRPAGDFNP
DADAKALRKAMKGLGTDEDTIIDIITHRSNAQRQQIRQTFKSHFGRDLMA
DLKSELSGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATR
TNAEIQAINKAYKEDYHKTLEDALSSDTSGHFKRILISLATGNREEGGED
RERAREDAQVAAEILTRFMMILCTRSYPDLRRVFQEFVKMTNYDVEHTIK
KEMSGDVRDVFVAIVQSVKNKPLFFADKLYKSMKGAGTEEKTLTRIMVSR
SEIDLLNIRREFIEKYDKSLHQAIEGDTSGHFLKALLAICGG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1avc Chain A Residue 677 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1avc Crystal structure of bovine annexin VI in a calcium-bound state.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		G188 E189 G193 E233
Binding residue
(residue number reindexed from 1)		G179 E180 G184 E224
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008201 heparin binding
GO:0019899 enzyme binding
GO:0035374 chondroitin sulfate binding
GO:0038024 cargo receptor activity
GO:0048306 calcium-dependent protein binding
GO:0051015 actin filament binding
Biological Process
GO:0003418 growth plate cartilage chondrocyte differentiation
GO:0006816 calcium ion transport
GO:0006937 regulation of muscle contraction
GO:0016192 vesicle-mediated transport
GO:0031214 biomineral tissue development
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051560 mitochondrial calcium ion homeostasis
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0030061 mitochondrial crista
GO:0031982 vesicle
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042584 chromaffin granule membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1avc, PDBe:1avc, PDBj:1avc
PDBsum1avc
PubMed9748523
UniProtP79134|ANXA6_BOVIN Annexin A6 (Gene Name=ANXA6)

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