Structure of PDB 1ak0 Chain A Binding Site BS04

Receptor Information
>1ak0 Chain A (length=264) Species: 5077 (Penicillium citrinum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WGALGHATVAYVAQHYVSPEAASWAQGILGSSSSSYLASIASWADEYRLT
SAGKWSASLHFIDAEDNPPTNCNVDYERDCGSSGCSISAIANYTQRVSDS
SLSSENHAEALRFLVHFIGDMTQPLHDEAYAVGGNKINVTFDGYHDNLHS
DWDTYMPQKLIGGHALSDAESWAKTLVQNIESGNYTAQAIGWIKGDNISE
PITTATRWASDANALVCTVVMPHGAAALQTGDLYPTYYDSVIDTIELQIA
KGGYRLANWINEIH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1ak0 Chain A Residue 274 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ak0 Recognition of single-stranded DNA by nuclease P1: high resolution crystal structures of complexes with substrate analogs.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H15 E181
Binding residue
(residue number reindexed from 1)		H15 E181
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) W1 H6 D45 R48 H60 H116 D120 H126 H149 D153
Catalytic site (residue number reindexed from 1) W1 H6 D45 R48 H60 H116 D120 H126 H149 D153
Enzyme Commision number 3.1.30.1: Aspergillus nuclease S1.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
Biological Process
GO:0006308 DNA catabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ak0, PDBe:1ak0, PDBj:1ak0
PDBsum1ak0
PubMed9726413
UniProtP24289|NUP1_PENCI Nuclease P1

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