Structure of PDB 5iqr Chain 8 Binding Site BS04

Receptor Information
>5iqr Chain 8 (length=615) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMVE
ILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKSVVNLIHGVRDMA
AIRQLKATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAERIAHLREVK
DAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRI
AKLLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQ
KKNLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANP
KPNGYQSIHTVVLGPGGKTVEIQIRTKQMHEDAELGVAAEDRVYVFTPKG
DVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEI
ITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRAAIGGGDIRLNA
EEQDAAALKQLQQKSYTPNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFI
TQGRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVAND
RSGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRV
LGKLNQVPDVIDARR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5iqr Chain 8 Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5iqr Ribosome-dependent activation of stringent control.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		C612 C613 H634
Binding residue
(residue number reindexed from 1)		C487 C488 H509
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.6.5: GTP diphosphokinase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008728 GTP diphosphokinase activity
GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0016301 kinase activity
Biological Process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0015969 guanosine tetraphosphate metabolic process
GO:0015970 guanosine tetraphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0042594 response to starvation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5iqr, PDBe:5iqr, PDBj:5iqr
PDBsum5iqr
PubMed27279228
UniProtP0AG20|RELA_ECOLI GTP pyrophosphokinase (Gene Name=relA)

[Back to BioLiP]