Structure of PDB 8ouw Chain 7 Binding Site BS04

Receptor Information
>8ouw Chain 7 (length=632) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYNTDWAAEKTKIRSFFDEYYVDNEDGSGKAFPYRDQVFEIARRDKQAIV
VNVDHIKESDIPDALELSEAITSNTKRYEVLFKDTISDMIQDYLGDKQAP
VIDALDAYMFQRLHMDRNLQDKRKKYPPQLLQRFEVYFTTDDAAHETCVR
NIKATEIGHLVSMKGVVIRATEVKPCVEVMTYTCDTCAAEVYQPVKGMQF
TPPVNCPNKECVEAKANGRLHMQLRGSKFVKFQELKIQELSEQVPVGSIP
RTMTVHVYGEMTRKCNTGNVVHVSGVFLPIMLVADTYLEAHYINNLDDNG
VQSAELEVLRRKGDNYETLAASIAPEIFGHVDVKKCLLMALVGGNDNSSN
GMKIRGCINVLMMGDPGVAKSQLLGYVNRLAPRSQYTTGRGSSGVGLTAA
VMKDPVTGEMSLEGGALVLADGGICCIDEFDKMMDHDRTAIHEVMEQQTI
SIAKAGIMTTLNARTAIIAAANPAYGRYNPNRSIEQNVDLPAALLSRFDL
ILLMQDKADRENDKILAEHITYVHQHGCHPNREKKDLISLETLREYISLC
KTYTPTVDPALRERIVEAYVEMRRDARYSSDPTFVSPRMILGIVRMATAR
AKLRLSTIVDESDVEEALRLMQFAKDSLRPEQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ouw Chain 7 Residue 1502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ouw DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans.
Resolution3.75 Å
Binding residue
(original residue number in PDB)		C197 C200 C219 C224
Binding residue
(residue number reindexed from 1)		C184 C187 C206 C211
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0009792 embryo development ending in birth or egg hatching
GO:0032508 DNA duplex unwinding
GO:0072689 MCM complex assembly
Cellular Component
GO:0005634 nucleus
GO:0042555 MCM complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ouw, PDBe:8ouw, PDBj:8ouw
PDBsum8ouw
PubMed37590372
UniProtO16297

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