Structure of PDB 8b9d Chain 6 Binding Site BS04

Receptor Information
>8b9d Chain 6 (length=607) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFV
DLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQD
LPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIR
DVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELP
RGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAET
ETEGIRGLRALGVRDLSYRLVFLACCVAPTAESIKNQMTVKEWEKVFEMS
QDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDIN
VCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHE
FVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKA
TLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECN
EVTDYAIARRIVDLHSRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQY
KHLRQRDGSGRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNK
SIIRVET
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8b9d Chain 6 Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8b9d How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C158 C161 C180 C185
Binding residue
(residue number reindexed from 1)		C142 C145 C164 C169
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:1990518 single-stranded 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902969 mitotic DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b9d, PDBe:8b9d, PDBj:8b9d
PDBsum8b9d
PubMed37506699
UniProtQ14566|MCM6_HUMAN DNA replication licensing factor MCM6 (Gene Name=MCM6)

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