Structure of PDB 8b9a Chain 4 Binding Site BS04

Receptor Information
>8b9a Chain 4 (length=628) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEPLRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEE
LYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMD
QTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDID
KLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCER
IDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDEL
VDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVITDQ
DLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTK
GGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAY
ITLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGI
ITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDK
VDEKNDRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPI
ITEAAKTELVRAYVGMRKMTATTRQLESMIRLAEAHAKMKLKNVVELEDV
QEAVRLIRSAIKDYATDPKTGKIDMNLV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8b9a Chain 4 Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8b9a How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		C349 C352 C371 C376
Binding residue
(residue number reindexed from 1)		C176 C179 C198 C203
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b9a, PDBe:8b9a, PDBj:8b9a
PDBsum8b9a
PubMed37506699
UniProtP30665|MCM4_YEAST DNA replication licensing factor MCM4 (Gene Name=MCM4)

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