Structure of PDB 6frk Chain y Binding Site BS03

Receptor Information
>6frk Chain y (length=424) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQELTLKYKLDNQF
ELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFD
FQNDFLRLLREAEESSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCE
SVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQR
RQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQ
LRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGF
DVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLV
KFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFV
GTGQTYCDLRSLNAKAVVAALMKA
Ligand information
Ligand IDGNP
InChIInChI=1S/C10H17N6O13P3/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24)/t3-,5-,6-,9-/m1/s1
InChIKeyUQABYHGXWYXDTK-UUOKFMHZSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)NP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)N[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)N[P](O)(O)=O)[CH](O)[CH]3O
FormulaC10 H17 N6 O13 P3
NamePHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
ChEMBLCHEMBL1233085
DrugBankDB02082
ZINCZINC000037868676
PDB chain6frk Chain y Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6frk Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		G427 G429 K430 S431 T432 N433 R457 Q463 G522 K588 D590 G614 G616 Q617
Binding residue
(residue number reindexed from 1)		G214 G216 K217 S218 T219 N220 R244 Q250 G309 K375 D377 G401 G403 Q404
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005047 signal recognition particle binding
GO:0005525 GTP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006886 intracellular protein transport
Cellular Component
GO:0005785 signal recognition particle receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6frk, PDBe:6frk, PDBj:6frk
PDBsum6frk
PubMed29567807
UniProtG1TCX6

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