Structure of PDB 6htq Chain x Binding Site BS03

Receptor Information
>6htq Chain x (length=341) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDMVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLD
HKLRTGDIVEILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENV
EKGRELVEKEIKNLDFELKDVLTPENIQKVADKFNFSNEEDMYAAVGYNG
ITALQVANRLTEKERKQRDQEEQEKIVQEVTGEPKPYPQGRKREAGVRVK
GIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVHREDCPNVKTNEAQERL
IPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNETKTNISSVS
GKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRR
Ligand information
>6htq Chain u (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggauagcucaguugguagagcaggggauugaaaauccccguguccu
ugguucgauuccgaguccgggcacca
<<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<
<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB6htq Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		T398 P399 K400 D402 I419 H420 S421 E422 I423 R478 K482 R486 K523 F524 N525 F526 S527 N528 E530 D531 Q545 N548 E681 K683 K715 R719
Binding residue
(residue number reindexed from 1)		T8 P9 K10 D12 I29 H30 S31 E32 I33 R88 K92 R96 K133 F134 N135 F136 S137 N138 E140 D141 Q155 N158 E291 K293 K325 R329
Enzymatic activity
Enzyme Commision number 2.7.6.5: GTP diphosphokinase.
External links
PDB RCSB:6htq, PDBe:6htq, PDBj:6htq
PDBsum6htq
PubMed32937119
UniProtO54408|RELA_BACSU GTP pyrophosphokinase (Gene Name=relA)

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