Structure of PDB 5tbw Chain s1 Binding Site BS03

Receptor Information
>5tbw Chain s1 (length=216) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVDPFTRKEWFDIKAPSTFENRNVGKTLVNKSTGLKSASDALKGRVVEVC
LADLQGSEDHSFRKIKLRVDEVQGKNLLTNFHGMDFTTDKLRSMVRKWQT
LIEANVTVKTSDDYVLRIFAIAFTRKQANQVKRHSYAQSSHIRAIRKVIS
EILTKEVQGSTLAQLTSKLIPEVINKEIENATKDIFPLQNIHVRKVKLLK
QPKFDVGALMALHGEG
Ligand information
Ligand IDOHX
InChIInChI=1S/6H2N.Os/h6*1H2;/q6*-1;+6
InChIKeyOWCQTVJQFLTQTE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
CACTVS 3.370
OpenEye OEToolkits 1.7.0		N[Os](N)(N)(N)(N)N
FormulaH12 N6 Os
Nameosmium (III) hexammine;
osmium(6+) hexaazanide
ChEMBL
DrugBank
ZINC
PDB chain5tbw Chain sR Residue 1911 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5tbw Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Q157 H160
Binding residue
(residue number reindexed from 1)		Q138 H141
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5tbw, PDBe:5tbw, PDBj:5tbw
PDBsum5tbw
PubMed29064494
UniProtP33442|RS3A1_YEAST Small ribosomal subunit protein eS1A (Gene Name=RPS1A)

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