Structure of PDB 7a5k Chain r1 Binding Site BS03

Receptor Information
>7a5k Chain r1 (length=696) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNEKIRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVMDS
MELERQRGITIQSAATYTMWKDVNINIIDTPGHVDFTIEVERALRVLDGA
VLVLCAVGGVQCQTMTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQMR
SKLNHNAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGQIVRYGEIPAE
LRAAATDHRQELIECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLKRS
FTPVFLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNKEDDSKEKTKI
LMNSSRDNSHPFVGLAFKLEVGRFGQLTYVRSYQGELKKGDTIYNTRTRK
KVRLQRLARMHADMMEDVEEVYAGDICALFGIDCASGDTFTDKANSGLSM
ESIHVPDPVISIAMKPSNKNDLEKFSKGIGRFTREDPTFKVYFDTENKET
VISGMGELHLEIYAQRLEREYGCPCITGKPKVAFRETITAPVPFDFTHKK
QSGGAGQYGKVIGVLEPLDPEDYTKLEFSDETFGSNIPKQFVPAVEKGFL
DACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALANA
TLCILEPIMAVEVVAPNEFQGQVIAGINRRHGVITGQDGVEDYFTLYADV
PLNDMFGYSTELRSCTEGKGEYTMEYSRYQPCLPSTQEDVINKYLE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7a5k Chain r1 Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7a5k Elongational stalling activates mitoribosome-associated quality control.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		T60 K80 T101
Binding residue
(residue number reindexed from 1)		T19 K39 T60
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0070125 mitochondrial translational elongation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a5k, PDBe:7a5k, PDBj:7a5k
PDBsum7a5k
PubMed33243891
UniProtQ96RP9|EFGM_HUMAN Elongation factor G, mitochondrial (Gene Name=GFM1)

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